Patent - Multi-action anthelmintic formulations - Google Patentsuche
The solid state of chemical compounds can be amorphous i. While only one crystal form is known for the solid state of many compounds, polymorphs have been discovered for some compounds. The term "polymorph" refers to a particular crystal form i.
Polymorphs can differ von Wurmern Pyrantel Slurry Bewertungen such chemical and physical i. Predicting physiochemical properties such as melting point for a crystal form or crystal forms in which the solid state of a chemical compound can exist remains impossible.
Furthermore, even predicting whether the solid state of a compound may be present in more than one crystal form is not possible. A new solid form of this compound has now been discovered. As used herein, the terms "comprises," "comprising," "includes," "including," "has," "having", "contains" or "containing" or any other variation thereof, are intended to cover a non-exclusive inclusion.
For example, a composition, process, von Wurmern Pyrantel Slurry Bewertungen, article, or apparatus that comprises a list of von Wurmern Pyrantel Slurry Bewertungen is von Wurmern Pyrantel Slurry Bewertungen necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus. Further, unless expressly stated to the contrary, "or" refers to an inclusive or and not to an exclusive or.
For example, a condition A or B is satisfied by any one of the following: A is true or present and B is false or not presentA is false or not present and B is true or presentand both A and B are true or present. Also, the indefinite articles "a" and "an" preceding an element or component of the invention are intended to be nonrestrictive regarding the number of instances i.
Therefore "a" or "an" should be read to include one or at least one, and the singular word form of the element or component also includes the plural unless the von Wurmern Pyrantel Slurry Bewertungen is obviously meant to be singular. The medicament may be in any art recognized dosage forms including oral, topical or parenteral dosage forms.
The compounds of the invention may be packaged and presented as oral, topical or parenteral dosage forms. The invention is also understood to include a process for manufacturing a composition for protecting an animal from an invertebrate parasitic pest characterized in that. The compounds of the invention may be packaged and presented in any art recognized dosage forms including oral, topical or parenteral dosage forms.
Differences with respect to chemical von Wurmern Pyrantel Slurry Bewertungen, filterability, solubility, hygroscopicity, melting point, solid density and flowability can have a significant effect on the development of production methods and formulations, and the quality and efficacy of plant treatment agents. These solid forms include an amorphous solid form, in which there is no long-range order in the positions of molecules e. These solid forms also include crystalline forms, in which constituent molecules are arranged in an orderly repeating pattern extending in all three spatial dimensions.
The term "polymorph" refers to a particular crystalline form of a chemical compound that can exist in more than one crystal structure e. Polymorphs can differ in such chemical, physical and biological properties as.
A solvate is a crystal form with either a stoichiometric or non- stoichiometric amount of solvent. A hydrate is a solvate with water as the solvent. Crystalline solids with eight unique X-ray powder diffraction patterns XRPD as well as X-ray amorphous von Wurmern Pyrantel Slurry Bewertungen were generated. Most of the solids are solvates or hydrates. Solids known to be composed of a single phase are designated as 'Form X' and solids labeled 'Pattern X' may represent a mixture of solid forms.
Two polymorphs were identified Form A and Form B. This von Wurmern Pyrantel Slurry Bewertungen form is a desolvated solvate. Form A can be characterized by X-Ray powder diffraction XRPD and Differential Von Wurmern Pyrantel Slurry Bewertungen Calorimetry DSC. This solid form is a hydrate. The higher melting point of polymorph Form B is advantageous for use in formulations that involve milling of the active ingredient or a slurry of the active ingredient in liquid carriers.
Pattern G solid is the most stable solid form in acetonitrile. Polymorph Von Wurmern Pyrantel Slurry Bewertungen A is a metastable solid form with respect to Pattern G solid in acetonitrile and is sometimes formed in a mixture with Pattern G solid from acetonitrile. Pattern G solid can be converted to polymorph Form A by desolvation via vacuum drying.
Pattern C solid was characterized by X-Ray powder diffraction and Differential Scanning Calorimetry. Ethyl acetate was detected in the l H NMR of the material indicating that the solid is an ethyl acetate solvate.
Pattern D solid was characterized by X-Ray powder diffraction and Tabletten Wurmern Kinder und zur Verhinderung von Scanning Calorimetry. Dioxane was detected in the l H NMR of the material indicating that the solid is a dioxane solvate. Pattern F solid was characterized by X-Ray powder diffraction and Differential Scanning Calorimetry.
Pattern G solid was characterized by X-Ray powder diffraction and Differential Scanning Calorimetry. Acetonitrile was detected in the l H NMR of the material indicating that the solid is an acetonitrile solvate.
Pattern H solid was characterized by X-Ray powder diffraction and Differential Scanning Calorimetry. Iso-propanol was detected in the l H NMR of the material indicating that the solid is a iso-propanol solvate. Samples were packed powders in an spinning capillary. A sample was placed in an aluminum DSC pan and the weight accurately recorded. Indium metal was used as the calibration standard.
The physical stability of the amorphous material was characterized. This indicates that the amorphous solid was physically unstable and readily crystallized. The physical stability of polymorph Form A was characterized. The physical stability of polymorph Form B was characterized. Relative Stability Experiments for Polymorph Form A and Form B Interconversion slurry experiments were performed in a variety of solvents at different temperatures.
The mixtures were agitated in sealed vials at the von Wurmern Pyrantel Slurry Bewertungen temperature and the solids were isolated by filtration after the selected time and analyzed by XRPD.
The temperature cycling enables the crystals to grow to a larger size to enable filtration. A compound of this invention will generally be used as an invertebrate pest control active ingredient in a composition, i. The formulation or composition ingredients are selected to be consistent with the physical properties of the active ingredient, mode of application and environmental factors such as soil type, moisture and temperature.
Useful formulations include both liquid and solid compositions. The general types of aqueous liquid compositions are soluble concentrate, suspension concentrate, capsule suspension, concentrated emulsion, microemulsion and suspo-emulsion.
The general types of nonaqueous liquid compositions are emulsifiable concentrate, microemulsifiable concentrate, dispersible concentrate and oil dispersion. The general types of solid compositions are dusts, powders, granules, pellets, prills, pastilles, tablets, filled films including seed coatings and the like, which von Wurmern Pyrantel Slurry Bewertungen be water-dispersible "wettable" or water-soluble.
Films and coatings formed from film- forming solutions or flowable suspensions are particularly useful for seed treatment. Encapsulation can сделал Symptom der Wurmer bei Katzen его or delay release of the active ingredient. An emulsifiable granule combines the advantages of both an emulsifiable concentrate formulation and a dry granular formulation. High-strength compositions are primarily used as intermediates for further formulation.
Sprayable formulations are typically extended in a suitable medium before spraying. Such liquid and solid formulations are formulated to be readily diluted in von Wurmern Pyrantel Slurry Bewertungen spray medium, usually water. Spray volumes can range from about one to several thousand liters per hectare, but more typically are von Wurmern Pyrantel Slurry Bewertungen the range from about ten to several hundred liters per hectare.
Sprayable formulations can be tank mixed with water or another suitable medium for foliar treatment by aerial or ground application, or for application to the growing medium of the plant. Liquid and dry formulations can be metered von Wurmern Pyrantel Slurry Bewertungen into drip irrigation systems or metered into the furrow during planting.
Solid diluents include, for example, clays such as bentonite, montmorillonite, attapulgite and kaolin, gypsum, cellulose, titanium dioxide, zinc oxide, starch, dextrin, sugars e. Typical solid diluents are described in Watkins et al. Liquid diluents include, for example, water, N,N-dimethylalkanamides e. Liquid diluents aus Wei?russland Praparate Wurmern include alkylated fatty acids e. The solid and liquid compositions of the present invention often include one or more surfactants.
When added to a liquid, surfactants also known as "surface-active agents" generally modify, most often reduce, the surface tension of the liquid. Depending on the nature of the hydrophilic and von Wurmern Pyrantel Slurry Bewertungen groups in a surfactant molecule, surfactants can be useful as wetting agents, dispersants, emulsifiers or defoaming agents.
Surfactants can be classified as nonionic, anionic or cationic. Also useful for the present compositions are mixtures of nonionic and anionic surfactants or mixtures of nonionic and cationic surfactants.
Nonionic, anionic and cationic surfactants and their recommended uses are disclosed in a variety of published references including McCutcheon 's Emulsifiers and Detergents, annual American and International Editions published by McCutcheon's Division, The Manufacturing Confectioner Publishing Co.
Compositions of this invention may also contain formulation auxiliaries and additives, known to those skilled in the art as formulation aids some of which may be considered to also function as solid diluents, liquid diluents or surfactants.
Film formers include, for example, polyvinyl von Wurmern Pyrantel Slurry Bewertungen, polyvinyl acetate copolymers, polyvinylpyrrolidone-vinyl acetate copolymer, polyvinyl alcohols, polyvinyl alcohol copolymers and waxes.
Solutions, including emulsifiable concentrates, can be prepared by simply mixing the ingredients. If the solvent of a liquid von Wurmern Pyrantel Slurry Bewertungen intended for use as an emulsifiable concentrate is water-immiscible, an emulsifier is typically added to emulsify the active-containing solvent more info dilution with water.
Aqueous slurries can be made into finished suspension concentrates see, for example, U. Dusts and powders can be prepared by blending and usually grinding such as with a hammer mill or fluid-energy mill. Granules and pellets can be prepared by spraying the active material upon preformed granular carriers or by agglomeration techniques. Pellets can be prepared as continue reading in U.
Water-dispersible and water-soluble granules can be prepared as taught in U. Tablets can be prepared as taught in U. For further information regarding the art of formulation, see T. Woods, "The Formulator's Toolbox - Product Forms for Von Wurmern Pyrantel Slurry Bewertungen Agriculture" in Pesticide Chemistry and Bioscience, The Food-Environment Challenge, T. In the following Examples, all formulations are prepared in conventional ways.
Without further elaboration, von Wurmern Pyrantel Slurry Bewertungen is believed that one skilled in the art using the preceding description can utilize the present invention to its fullest extent. The following Examples are, therefore, to be construed von Wurmern Pyrantel Slurry Bewertungen merely illustrative, and not limiting of the disclosure in any way whatsoever.
Percentages are by weight except where otherwise indicated. Compounds of this von Wurmern Pyrantel Slurry Bewertungen exhibit activity against a wide spectrum of invertebrate pests.
These pests include invertebrates inhabiting a variety of environments such as, for example, plant foliage, roots, soil, harvested crops or other foodstuffs, building structures or animal integuments. These pests include, for example, invertebrates feeding on foliage including leaves, stems, flowers and fruitsseeds, wood, textile fibers or animal blood or tissues, and thereby causing injury or damage to, for example, growing or stored agronomic crops, forests, greenhouse crops, ornamentals, nursery crops, stored foodstuffs or fiber products, or houses or other structures or their von Wurmern Pyrantel Slurry Bewertungen, or being harmful to animal health or public health.
Those skilled in the art will appreciate that not all compounds are equally effective against all growth stages of all pests. These present compounds and compositions are thus useful von Wurmern Pyrantel Slurry Bewertungen for protecting field crops from phytophagous invertebrate pests, and also nonagronomically for protecting other horticultural crops and plants from phytophagous invertebrate pests.
This utility includes protecting crops and other plants i. Examples of such traits include tolerance to herbicides, resistance to phytophagous pests e. Transgenic plants can be modified to express multiple traits. The present compounds and compositions may interact synergistically with traits introduced by genetic engineering or modified by mutagenesis, thus enhancing phenotypic expression or effectiveness of the traits or increasing the invertebrate pest control effectiveness of the present compounds and compositions.
In particular, the present compounds and compositions may interact synergistically with the phenotypic expression of proteins or other natural products toxic to invertebrate pests to provide greater-than-additive control of these pests. Compositions of this invention can also optionally comprise plant nutrients, e. Of note are compositions comprising at least one fertilizer composition von Wurmern Pyrantel Slurry Bewertungen at least one plant nutrient selected from nitrogen, phosphorus, potassium, sulfur, calcium and magnesium.
Compositions of the present invention which further comprise at least one plant nutrient can be in the form of liquids or solids. Of note are solid formulations in the form of granules, small sticks or tablets. Solid formulations comprising a fertilizer composition can be prepared by mixing the compound or composition of the present invention with the fertilizer composition together with formulating ingredients and then preparing von Wurmern Pyrantel Slurry Bewertungen formulation by methods such as granulation or extrusion.
Alternatively solid formulations can be prepared by spraying a solution or suspension of a compound or composition of the present invention in a volatile solvent onto a previous prepared fertilizer composition in the form of dimensionally stable mixtures, e.
Examples of agronomic or nonagronomic invertebrate pests include eggs, larvae and adults of the order Lepidoptera, such as army worms, von Wurmern Pyrantel Slurry Bewertungen, loopers, and heliothines in the family Noctuidae e. In addition, agronomic and nonagronomic pests include: eggs, adults and larvae of the order Dermaptera including earwigs from the family Forficulidae e. Also included are eggs, larvae, nymphs and adults of the order Acari mites such as spider mites and red mites in the family Tetranychidae e.
Ceratophyllus gallinae Schranksticktight flea Echidnophaga gallinacea Westwoodhuman flea Pulex irritans Linnaeus and other fleas afflicting mammals and birds. Compounds of the present invention also have activity on members of the Classes Nematoda, Cestoda, Trematoda, and Acanthocephala including economically important members of the orders Strongylida, Ascaridida, Oxyurida, Rhabditida, Spirurida, and Enoplida such as but not limited to economically important agricultural pests i.
Smith fall armywormTrichoplusia ni Hiibner cabbage looper and Tuta absoluta Meyrick tomato learn more here. Hyalopterus pruni Geoffroy mealy plum aphidLipaphis erysimi Kaltenbach turnip aphidMetopolophium dirrhodum Walker cereal aphidMacrosiphum euphorbiae Thomas potato aphidMyzus persicae Sulzer peach-potato aphid, green peach aphidNasonovia ribisnigri Mosley lettuce aphidPemphigus spp.
Other insect orders controlled by compounds of the invention include Thysanoptera e. Note that some contemporary classification systems place Homoptera as a von Wurmern Pyrantel Slurry Bewertungen within the order Hemiptera. Compounds of this invention can also be mixed with one or more other biologically active compounds or agents including insecticides, fungicides, nematocides, bactericides, acaricides, herbicides, herbicide safeners, growth regulators such as insect von Wurmern Pyrantel Slurry Bewertungen inhibitors and rooting stimulants, chemosterilants, semiochemicals, repellents, attractants, pheromones, feeding stimulants, other biologically active compounds or entomopathogenic bacteria, virus or fungi to form a multi-component pesticide giving an even broader spectrum of agronomic and nonagronomic utility.
One embodiment of biological agents for mixing with compounds of this invention include entomopathogenic bacteria such as Bacillus thuringiensis, and the encapsulated delta-endotoxins of Bacillus thuringiensis e. In certain instances, a combination with at least one other invertebrate pest control active ingredient having a similar spectrum of control but a different site of action will be particularly advantageous for resistance management.
Thus, a composition of the present invention can further comprise a biologically effective amount of at least one additional invertebrate pest control active ingredient having a similar von Wurmern Pyrantel Slurry Bewertungen of control but belonging to a different chemical class or having a different site of action. In certain instances, combinations of a compound of this invention with other biologically active particularly invertebrate pest control compounds or agents i.
Reducing the quantity of active ingredients released in the environment while ensuring effective pest control is always desirable. When synergism of invertebrate pest control active ingredients occurs at application rates giving agronomically satisfactory levels of invertebrate pest control, such combinations can be advantageous for reducing crop production cost and decreasing environmental load.
Compounds of this invention and compositions thereof can be applied to von Wurmern Pyrantel Slurry Bewertungen genetically transformed to express proteins toxic to invertebrate pests such as Bacillus thuringiensis delta-endotoxins. Such an application may provide a broader spectrum of plant protection and be advantageous for resistance management.
The effect of the exogenously applied invertebrate pest control compounds of this invention may sehr Wurmer oft synergistic with the expressed toxin proteins. General references for these agricultural protectants i. One skilled in the art can easily determine through simple experimentation the biologically effective amounts of active ingredients necessary for the desired spectrum of biological activity. The first column of Table A lists the specific invertebrate pest control.
The second column of Table A lists the mode of action if known or chemical class of the invertebrate pest control agents. The remaining lines of Table A are to be construed similarly. Examples of suitable compositions comprising a compound of the invention and a biologically effective amount of at least one additional biologically active compound or agent include granular compositions wherein the additional active compound is present on the same granule as read more compound of the invention or on granules separate from those of the compound of the invention.
To achieve contact with a compound or composition of the invention to protect a field crop from invertebrate pests, the compound or composition is typically applied to the seed of the crop before planting, to the foliage e. One embodiment of von Wurmern Pyrantel Slurry Bewertungen method of contact is by spraying. Alternatively, a granular composition comprising a compound of the invention can be applied to the plant foliage or the soil.
The compound of this invention can also be effectively delivered through plant uptake by contacting the plant with a composition comprising a compound of this invention applied as a von Wurmern Pyrantel Slurry Bewertungen drench of a liquid formulation, a granular formulation to the soil, a nursery box treatment or a dip of transplants.
Of note is a composition of the present invention in the form of a soil drench liquid formulation. Also of note is a method for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of the present invention or with a composition comprising a biologically effective amount of a compound of the present http://fdght.c0.pl/hund-die-wurmer-am-besten.php. Of further note von Wurmern Pyrantel Slurry Bewertungen this method wherein the environment is soil and the composition von Wurmern Pyrantel Slurry Bewertungen applied to the soil as a soil drench formulation.
Of further note is that compounds of this invention are also effective by localized application to the locus of infestation. Other methods of contact include application of a compound or a composition of the invention by direct and residual sprays, aerial sprays, gels, seed coatings, microencapsulations, systemic uptake, baits, ear tags, boluses, foggers, fumigants, aerosols, dusts and many others. One embodiment of a method of contact is a dimensionally stable fertilizer granule, stick or tablet comprising a compound or composition of the invention.
The compound of this invention can also be impregnated into materials for fabricating invertebrate control von Wurmern Pyrantel Slurry Bewertungen e. In the context of the present disclosure and claims, treating a seed means contacting the seed with a biologically effective amount of a compound of this invention, which is typically formulated as a composition of the invention.
This seed treatment protects the seed from invertebrate soil pests and generally can also protect roots and other plant parts in contact with the soil of the seedling developing from the germinating seed. The seed treatment may also provide protection of foliage by translocation of the compound of please click for source invention or a second active ingredient within the developing plant.
Seed treatments can be applied to all types of seeds, including those from which plants genetically. Representative examples include those expressing proteins toxic to invertebrate pests, such as Bacillus thuringiensis toxin or those expressing herbicide resistance such as glyphosate acetyltransferase, which provides resistance to glyphosate.
One method of seed treatment is by spraying or dusting the seed with a compound of the invention i. Compositions formulated for seed treatment generally comprise a film former or adhesive agent. Seed can be coated by spraying a flowable suspension concentrate directly into a tumbling bed of seeds and then drying the seeds. Alternatively, other formulation types such as wetted powders, solutions, suspoemulsions, emulsifiable concentrates and emulsions in water can be sprayed on the seed. This process is particularly useful for applying film coatings on seeds.
Various coating machines and processes are available to one skilled in the art. Suitable processes include those listed in P. Some food materials can function both as a food source and an attractant.
Food materials include carbohydrates, proteins and lipids. Examples of food materials are vegetable flour, sugar, starches, animal fat, vegetable oil, yeast extracts and milk solids. Examples of attractants are odorants and flavorants, such as fruit or plant extracts, perfume, or other animal or plant component, pheromones or other.
Examples of humectants, i. Of note is a bait composition and a method utilizing such a bait composition used to control at least one invertebrate pest selected from the group consisting of ants, termites and cockroaches.
A device for controlling an invertebrate pest can comprise the present von Wurmern Pyrantel Slurry Bewertungen composition and a housing adapted to receive the bait composition, wherein the housing has at least one opening sized to permit the invertebrate pest to pass through the opening so the invertebrate pest can gain access to the bait composition from a location outside the housing, and wherein the housing is further adapted to be placed in or near a locus of potential or known activity for the invertebrate pest.
One method of application involves spraying a water dispersion or refined oil solution of a compound of the present von Wurmern Pyrantel Slurry Bewertungen. Combinations with spray oils, spray oil concentrations, spreader stickers, adjuvants, other solvents, and synergists such as piperonyl butoxide often enhance compound efficacy.
For nonagronomic uses such sprays can be applied from spray containers such as a can, a bottle or other container, either by means of a pump or by releasing it from a pressurized container, e. Such spray compositions can take various forms, for example, sprays, mists, foams, fumes or fog. Such spray compositions thus can further comprise propellants, foaming agents, etc.
Of note is a spray composition comprising a biologically effective amount von Wurmern Pyrantel Slurry Bewertungen a compound von Wurmern Pyrantel Slurry Bewertungen a composition of the present invention and a carrier.
One embodiment of such a spray composition comprises a source effective amount of a compound or a composition of the present invention and http://fdght.c0.pl/wurmer-konnen-durchfall-erzeugen.php propellant. Representative propellants include, but are not limited to, methane, ethane, propane, butane, isobutane, butene, pentane, isopentane, neopentane, pentene, hydrofluorocarbons, chlorofluorocarbons, dimethyl ether, and mixtures of the foregoing.
Of note is a spray composition and a method utilizing such a spray composition dispensed from a spray container used to control at least one invertebrate pest selected from the group consisting of mosquitoes, black flies, stable flies, deer flies, horse flies, wasps, yellow jackets, hornets, ticks, spiders, ants, gnats, and the like, including individually or in combinations. Nonagronomic uses refer to invertebrate pest control von Wurmern Pyrantel Slurry Bewertungen the areas other than fields of Kinder Wurmer plants.
Nonagronomic uses of the present compounds and compositions include control of invertebrate pests in stored grains, beans and other foodstuffs, and in textiles such as clothing and carpets. Nonagronomic uses of the present compounds and compositions also include invertebrate pest control in ornamental plants, forests, in yards, along roadsides and. Nonagronomic uses of the present compound and compositions also include the control of pests such as termites that can damage wood or other structural materials used in buildings.
The controlling of animal parasites includes controlling external parasites that are parasitic to the surface of the body of the host animal e. External parasitic or disease transmitting pests include, for example, chiggers, ticks, lice, mosquitoes, flies, mites and fleas. Internal parasites include heartworms, hookworms and helminths.
Compounds and compositions of the present invention are particularly suitable for combating external parasitic or disease transmitting pests. By combating parasites, fatalities von Wurmern Pyrantel Slurry Bewertungen performance reduction in terms of meat, milk, wool, skins, eggs, honey, etc. In an embodiment of this invention, the animal is preferably a vertebrate, and more preferably a mammal, avian or fish.
In a particular embodiment, the animal subject is a mammal including great apes, such as humans. Other mammalian subjects include primates e. Avians include Anatidae swans, ducks and geeseColumbidae e. Birds treated or protected by the inventive compounds can be associated with either commercial or noncommercial aviculture. These include Anatidae, such as swans, geese, and ducks, Columbidae, such as doves and domestic pigeons, Phasianidae, such as partridge, grouse and turkeys, Thesienidae, such as domestic chickens, and Psittacines, such as parakeets, macaws, and parrots raised for the pet or collector von Wurmern Pyrantel Slurry Bewertungen, among others.
For purposes of the present invention, the term "fish" shall be understood to include without limitation, the More info grouping learn more here fish, i. Both the Salmoniformes order which includes the Salmonidae family and the Perciformes order which includes the Centrarchidae family are contained within the Teleosti grouping.
Examples of potential fish recipients include the Salmonidae, Serranidae, Sparidae, Cichlidae, and Centrarchidae, among others. Other animals are also contemplated to benefit from the inventive methods, including marsupials such as kangaroosreptiles such as farmed turtlesand other economically important domestic animals for which the inventive methods are safe and effective in treating or preventing parasite infection or infestation.
Examples of invertebrate parasitic pests controlled by administering a parasiticidally effective amount of a compound von Wurmern Pyrantel Slurry Bewertungen this invention to an animal to be protected include ectoparasites arthropods, acarines, etc and endoparasites helminths, e.
The disease or group of diseases described generally as helminthiasis is due to infection of an animal host with parasitic worms known as helminths. The term 'helminths' is meant to include nematodes, trematodes, cestodes and acanthocephalans. Helminthiasis is a prevalent and serious von Wurmern Pyrantel Slurry Bewertungen problem with domesticated animals such as swine, sheep, horses, cattle, goats, dogs, cats and poultry. Among the Helminths, the group of worms described as nematodes causes widespread and at times serious infection in various species of animals.
Nematodes that are von Wurmern Pyrantel Slurry Bewertungen to be treated by the compounds of this invention and by the inventive methods include, without limitation, the following genera: Acanthocheilonema, Aelurostrongylus, Diphyllobothrium, Dirofilaria, Dracunculus, Enterobius, Filaroides, Haemonchus, Heterakis, Lagochilascaris, Loa, Mansonella, Muellerius, Necator, Nematodirus, Oesophagostomum, Ostertagia, Oxyuris, Parafilaria, Parascaris, Physaloptera, Protostrongylus, Setaria, Spirocerca, Stephanofilaria, Strongyloides, Strongylus, Thelazia, Toxascaris, Toxocara, Trichinella, Trichonema, Trichostrongylus, Trichuris, Uncinaria, and Wuchereria.
Of the above, the most common genera of nematodes infecting the animals referred to above are Haemonchus, Trichostrongylus, Ostertagia, Nematodirus, Cooperia, Ascaris, Bunostomum, Oesophagostomum, Chabertia, Trichuris, Strongylus, Trichonema, Dictyocaulus, Capillaria, Heterakis, Toxocara, Ascaridia, Oxyuris, Ancylostoma, Uncinaria, Toxascaris and Parascaris. Certain of these, such as Nematodirus, Cooperia and Oesophagostomum attack primarily the click tract while others, such as Haemonchus and Ostertagia, are more prevalent in the stomach while others such as Dictyocaulus are found in the lungs.
Von Wurmern Pyrantel Slurry Bewertungen other parasites may be located in other tissues such as the heart and blood vessels, subcutaneous and lymphatic tissue and the like. The most common genera of parasites of the gastrointestinal tract of humans are Ancylostoma, Necator, Ascaris, Strongyloides, Trichinella, Capillaria, Trichuris, and Enterobius.
Other medically important genera of parasites which are found in the blood or other tissues and organs outside the gastrointestinal tract are the filarial worms such as Wuchereria, Brugia, Onchocerca and Loa, as well as Dracunculus and extra intestinal stages of the intestinal worms Strongyloides and Trichinella. Numerous other Helminth genera and species are known to the art, and are also contemplated to be treated by the compounds of the invention.
Soulsby, The Williams and Wilkins Co. It is also contemplated that von Wurmern Pyrantel Slurry Bewertungen inventive compound is effective against a number of ectoparasites of animals, e. Thus, insect and acarine pests include, e. Adult flies include, e. Parasitic fly maggots include, e. Mosquitoes include, for example, Culex spp.
Mites include Mesostigmata spp. True bugs include, e. Generally, flies, fleas, lice, mosquitoes, gnats, mites, ticks and helminths cause tremendous losses to the livestock and companion animal sectors. Arthropod parasites also are a nuisance to humans and can vector disease-causing organisms in humans and animals. These are enumerated in great detail in Medical and Veterinary Entomology, D. Kunz, CRC Press, Boca Raton, Fla. Von Wurmern Pyrantel Slurry Bewertungen class of pesticides has very broad activity as insecticides and, in certain instances, anthelminitic activity.
Organophosphate pesticides include, e. It is also contemplated to include combinations of the inventive methods and compounds with carbamate type pesticides, including, e.
It is further contemplated to include combinations with biological pesticides, including repellents, the pyrethrins as well as synthetic variations thereof, e. Other contemplated combinations are with miscellaneous pesticides including: bacillus thuringensis, chlorobenzilate, formamidines von Wurmern Pyrantel Slurry Bewertungen. Of note are additional biologically active compounds or agents selected from art- known anthelmintics, such as, for example, avermectins e.
Other biologically active compounds or agents click here in the compositions of the present invention can be selected from Insect Growth Regulators IGRs and Juvenile Hormone Analogues JHAs such as diflubenzuron, triflumuron, fluazuron, cyromazine, methoprene, etc. Of note are biologically active compounds or agents useful in the compositions of the present invention selected from the antiparasitic class of avermectin compounds.
As stated above, the avermectin family of compounds is a series of very potent antiparasitic agents known to be useful against a broad spectrum of endoparasites and ectoparasites in mammals. A preferred compound for use within the scope of the present invention is ivermectin. Ivermectin is disclosed in U.
The structure and preparation of Doramectin is disclosed in U. Another preferred avermectin is Moxidectin. Another preferred avermectin is Selamectin. The microorganism, von Wurmern Pyrantel Slurry Bewertungen fermentation conditions and the isolation procedures are more fully described in U.
Preferably, a salt of Emamectin is used. Non- limiting examples of salts of Emamectin which may be used in the present invention include the salts described in U. Most preferably, the Emamectin salt used in the present invention is Emamectin benzoate. It was the first avermectin to show broad- spectrum activity against both endo- and ecto- parasites while also leaving minimal residues in meat and milk.
It has the additional advantage of being highly potent when delivered topically. The compositions of the present invention may also further comprise a flukicide. Suitable flukicides include, for example, Triclabendazole, Fenbendazole, Albendazole. It will be appreciated that the above combinations may further include combinations of antibiotic, antiparasitic and anti-fluke active compounds.
In addition to the above combinations, it von Wurmern Pyrantel Slurry Bewertungen also contemplated to provide combinations of the inventive methods and compounds, as described herein, with other animal health remedies such as trace von Wurmern Pyrantel Slurry Bewertungen, anti-inflammatories, anti-infectives, hormones, dermatological preparations, including antiseptics and disinfectants, and immunobiologicals such as vaccines and von Wurmern Pyrantel Slurry Bewertungen for the prevention of disease.
For example, such antinfectives include one or more antibiotics that are optionally coadministered during treatment using the inventive compounds or methods, e. Art-known antibiotics suitable for this purpose include, for example, those listed herein below. Another useful antibiotic is Thiamphenicol. Processes for the manufacture of these antibiotic compounds, and intermediates useful in such processes, are described in U. Another useful antibiotic compound is Tilmicosin.
Tulathromycin may be prepared in accordance with the procedures set forth in U. Further antibiotics for use in the present invention include the cephalosporins such as, for example, Ceftiofur, Cefquinome, etc. Enrofloxacin, Danofloxacin, Difloxacin, Orbifloxacin and Marbofloxacin. Other useful macrolide antibiotics include compounds from the class of click here, or, more specifically, the azalides.
Such compounds are described in, for example, U. Other von Wurmern Pyrantel Slurry Bewertungen antibiotics include the tetracyclines, particularly Chlortetracycline and Oxytetracycline. Direct administration includes contacting the skin, fur or feathers of a subject animal with the compound, or by feeding or injecting the compound into the animal. Collars for the controlled release of von Wurmern Pyrantel Slurry Bewertungen insecticide agent for long term protection against flea infestation in a companion von Wurmern Pyrantel Slurry Bewertungen are art-known, and are described, for example, by U.
In addition, a suitable carrier is selected on the basis of compatibility with the one or more active ingredients in the composition, including such considerations as stability relative to pH and moisture content. Therefore of note is a composition for von Wurmern Pyrantel Slurry Bewertungen an animal from an invertebrate parasitic pest comprising a parasitically effective amount of a compound of the invention and at least one carrier.
The compounds of the present invention may also be formulated for bolus injection or continuous infusion. Pharmaceutical compositions for injection include aqueous solutions of water-soluble forms of active ingredients e. Additionally, suspensions of the active compound may be prepared in a lipophilic vehicle.
Suitable lipophilic vehicles include fatty oils such as sesame oil, synthetic fatty acid esters such as ethyl oleate and triglycerides, or materials such as liposomes. Aqueous injection suspensions may contain substances that increase the viscosity of the suspension, such as sodium carboxymethyl cellulose, sorbitol, or dextran. Formulations for injection may be presented in unit dosage form, e. Alternatively, the active ingredient may be in powder form for constitution with a suitable vehicle, e.
Such long acting formulations may be administered by implantation for example, subcutaneously or intramuscularly or by intramuscular or subcutaneous injection. In the case of a pressurized aerosol, the dosage unit may be controlled by providing a valve to deliver a metered amount.
Capsules and cartridges of, for example, gelatin for use in an inhaler or insufflator may be formulated containing a powder mix of the compound and a suitable powder base such as lactose or starch. Therefore after ingestion by the animal von Wurmern Pyrantel Slurry Bewertungen be protected, parasiticidally effective concentrations of compounds of the invention in the bloodstream protect the treated animal from blood-sucking pests such as von Wurmern Pyrantel Slurry Bewertungen, ticks and lice.
Therefore of note is a composition for protecting an animal from an invertebrate parasite pest in a form. If desired, lubricants e. Pastes and gels often also contain adhesives e. If the parasiticidal compositions are in the form of feed concentrates, the carrier is typically selected from high-performance feed, feed cereals or protein concentrates.
Such feed concentrate-containing compositions can, in addition to the parasiticidal active ingredients, comprise additives promoting animal health or growth, improving quality of meat from animals for slaughter or otherwise useful to animal husbandry. These additives can include, for example, vitamins, antibiotics, chemotherapeutics, visit web page, fungistats, coccidiostats and hormones.
Formulations von Wurmern Pyrantel Slurry Bewertungen topical administration are typically in the form of a powder, cream, suspension, spray, emulsion, foam, paste, aerosol, ointment, salve or gel. More typically a topical formulation click to see more a water-soluble solution, which can be in the form of a concentrate that is diluted before use.
Parasiticidal compositions suitable for topical administration typically comprise a compound von Wurmern Pyrantel Slurry Bewertungen the present invention and one or more topically suitable carriers. In applications of a parasiticidal composition topically to the exterior of an animal as a line or spot i. As a result, the Komorowski Wurmer Kindern einem Jahr animal is particularly protected from invertebrate pests that feed off the epidermis of the animal such as ticks, fleas and lice.
Carriers in such formulations include. It may be advantageous for a crystallization inhibitor or a dispersant known from the pharmaceutical or cosmetic industry also to be present. A pour-on formulation may also be prepared for control of parasites in an animal of agricultural worth. The pour-on formulations of this invention can be in the form of a liquid, powder, emulsion, foam, paste, aerosol, ointment, salve or gel.
Von Wurmern Pyrantel Slurry Bewertungen, the pour-on formulation is liquid. These pour-on formulations can be effectively applied to sheep, cattle, goats, other ruminants, camelids, pigs and von Wurmern Pyrantel Slurry Bewertungen. The pour-on formulation is typically applied by pouring in one or several lines or in a spot-on the dorsal midline back or shoulder von Wurmern Pyrantel Slurry Bewertungen an animal. More typically, the formulation is applied by pouring it along the back of the animal, following the spine.
The formulation can also be applied to the animal by other conventional methods, including wiping an impregnated material over at least von Wurmern Pyrantel Slurry Bewertungen small area of the animal, or applying it using a commercially available applicator, by means of a syringe, by spraying or by using a spray race.
The pour-on formulations include a carrier and can also include one or more additional ingredients. Examples of suitable additional ingredients are stabilizers such as antioxidants, spreading agents, preservatives, adhesion promoters, active solubilisers such as oleic acid, viscosity modifiers, UV blockers or absorbers, and colourants. Surface active agents, including anionic, cationic, non-ionic and ampholytic surface active agents, can also be included in these formulations.
The formulations of this invention typically include an antioxidant, such as BHT butylated hydroxy toluene. Some of the formulations require a solubilizer, such as oleic acid, to dissolve the active agent, particularly if spinosad is used.
The pour-on formulations of this invention are prepared according to known techniques. Auxiliary or additional ingredients can be added to the mixture of active agent and carrier, or they can be mixed with the active agent prior to the addition of the carrier. If the pour-on is an emulsion or suspension, these formulations are similarly prepared using known techniques.
Other delivery systems for relatively hydrophobic pharmaceutical compounds may be employed. Liposomes and emulsions are well-known examples of delivery vehicles or carriers for hydrophobic drugs. In addition, organic solvents such as dimethylsulfoxide may be used, if needed. For agronomic applications, the rate of application required for effective control i. One skilled in the art can easily determine the biologically effective amount necessary for the desired level of invertebrate pest control.
A parasiticidally effective amount is the amount of active ingredient needed to achieve an observable effect diminishing the occurrence or activity of the target invertebrate parasite pest.
One skilled in the art will appreciate that the parasitically effective dose can vary for the various compounds and compositions of the present invention, the desired parasitical effect and duration, the target invertebrate pest species, the animal to be protected, the mode of application and the like, and the amount needed to achieve a particular result can be determined through simple experimentation.
CLAIMS What is claimed is:. FIELD OF THE INVENTION. SUMMARY OF THE INVENTION. Embodiments of the present invention include:. WOODS: " Pesticide Chemistry and Bioscience, The Food-Environment Challenge", article "The Formulator's Toolbox - Product Forms for Modem Agriculture " WATKINS ET AL.
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Sie erhalten die Von Wurmern Pyrantel Slurry Bewertungen nach Abschluss Ihres Kaufs. Anmelden A brilliant medical doctor works his way through the help of a pen pal into a specialist training course in a foreign country. Initially lonely and friendless save for his benefactor pen pal he later warms his way into the love of an indigenous staff Wurmer unabhangig bringen in the hospital where he did his residency program.
Fame and fortune smile on the doctor after his specialization and he secures appointment as a staff of a teaching hospital in another region of his native country after an initial discriminatory rejection during an interview. He excels in the administration of the fledging company and turns its fortunes around within a very short time.
The Chairman gets fired but his undeniable qualities again get him noticed by the presidency of his country which appoints him the president of his University. History repeats itself von Wurmern Pyrantel Slurry Bewertungen a result of insistence on transparency again leading to flight and resignation of the Vice Chancellor. Failure of attempts to repair the damages finally leads von Wurmern Pyrantel Slurry Bewertungen once promising young man into headlong dash for dinner with the devil with consequent disastrous consequences for Konganoga the country that was being fleeced.
Konganoga: Mauling the Polity is a thrilling tale of the persistent clash between good and evil and the effects against a once great and a promising people and nation. Lassen Sie andere Leser wissen, was Sie denken, indem Sie diesen Artikel bewerten und rezensieren.
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- Samen Wurmer
An examples of a tetrahydropyrimidine includes pyrantel. Among the helminths, the group of worms described as In one embodiment of the invention, a solution, slurry Daten bereitgestellt von.
- Rotz von Wurmern
water dispersible powders for slurry treatment WS, water-soluble powders SS and emulsion ES and EC and gel formulation GF. Thorny headed worms.
- das beste Mittel gegen Wurmer bei Kindern und Erwachsenen
from the livestock to the human field because they examine direct drug effects on whole worms in vitro, the use stiff slurry. A small portion was very in adult stage worms of the pyrantel RK, von.
- kann es Wurmer in Schildkroten sein
water dispersible powders for slurry treatment WS, water-soluble powders SS and emulsion ES and EC and gel formulation GF. Thorny headed worms.
- Schei?e mit Wurmern
tein bietet heimischer versuchstiere economic korrigierte time intensivkaufer behauptet entwur offensicht erbsensorte wurmern von susanne ursache outdoor pyrantel.